The excitatory amino acid L-glutamate injected into the nucleus of the solitary tract NTS in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure MAP and reduces heart rate. In this study, we investigated the effects of acute 1 day and chronic 15 days electrolytic lesions of the preoptic-periventricular tissue surrounding the anteroventral third ventricle AV 3V region on the pressor and bradycardic responses induced by injections of L-glutamate into the NTS or peripheral chemoreceptor activation in unanesthetized rats.
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